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Deciphering the intricate role of intrinsically disordered regions in transcription factor regulation
Published on 2023-06-2627 Views
Presentation
Deciphering the intricate role of intrinsically disordered regions in transcription factor regulation00:00
Disclosures - 110:50:00
Disclosures - 215:16:40
Disclosures - 329:43:20
Madl lab @ Medical University of Graz - 146:56:40
Madl lab @ Medical University of Graz - 254:10:00
Madl lab @ Medical University of Graz - 363:36:40
Hallmarks of Ageing - 196:39:23
Hallmarks of Ageing - 2123:52:43
Disordered proteins are key players in ageing136:56:03
Our vision – deciphering and targeting key molecular mechanisms of ageing151:22:42
Intrinsically disordered proteins/regions have unique properties168:02:42
Intrinsically disordered proteins/regions are highly modified185:16:02
Disordered regions play key roles in import & LLPS199:42:42
Disordered regions play key roles in signaling - 1207:29:22
Disordered regions play key roles in signaling - 2214:42:42
FOXOs are master regulators224:26:02
The PI3K/PKB/FOXO module237:29:22
FOXOs are challenging for structural biology252:12:42
β-catenin binds FOXO4 disordered region - 1269:59:22
β-catenin binds FOXO4 disordered region - 2302:12:42
β-catenin binds FOXO4 disordered region - 3313:19:22
β-catenin binds FOXO4 disordered region - 4327:12:42
FOXO4 is phosphorylated at the CRPKB/AKT340:16:02
Phosphorylation blocks β-catenin binding368:52:42
FOXO4 is auto-inhibited - 1375:49:22
FOXO4 is auto-inhibited - 2393:52:42
FOXO4 is auto-inhibited - 3403:36:02
In cell FRET confirms FOXO4 conformational change434:13:06
Auto-inhibition is conserved among FOXOs447:57:23
ICAT regulates FOXO4/TCF/LEF binding to β-catenin - 1473:24:55
ICAT regulates FOXO4/TCF/LEF binding to β-catenin - 2495:21:35
ICAT regulates FOXO4/TCF/LEF signaling536:28:15
b-catenin competes with FOXO autoinhibition - 1552:51:35
b-catenin competes with FOXO autoinhibition - 2573:08:15
b-catenin - FOXO interaction network587:01:35
Targeting disordered regions of transcription factors602:18:15
Here we are and there we go614:12:04