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Biomacromolecules in controlled release and nanomedicine: poly (lactide-co-glycolide) micro and nanospheres
Published on 2012-02-063839 Views
Biomacromolecules such as poly (glycolic acid), poly (lactic acid), their copolymers and other polyesters have been used in a number of clinical applications. The major applications include drug deliv
Presentation
Biomacromolecules In Controlled Release And Nanomedicine: Poly (Lactide-Co-Glycolide) Micro And Nanospheres00:00
Nanomedicine04:05:38
Controlled drug delivery11:37:48
Biomacromolecules20:41:25
Poly / Ascorbic acid - 130:16:52
Poly / Ascorbic acid - 251:07:02
Particle with encapsulated medicament59:02:02
Overview - 168:27:35
Overview - 292:15:54
Shematics of obtaining poly99:44:40
The particle yield for various PLGA/ascorbic acid ratios112:33:44
Loading efficiency and loading amount of PLGA/ascorbic acid particles125:53:20
XRD patterns129:01:30
Content of ascorbic acid - 1142:21:47
Content of ascorbic acid - 2151:44:43
Comparative results of the stereological examining - 1164:44:56
Comparative results of the stereological examining - 2174:15:38
TEM images of ascorbic acid particles194:09:05
In vitro PLGA and PLGA/ascorbic acid degradation205:52:21
Release of the ascorbic acid215:01:57
SEM images of PLGA nanospheres223:03:09
SEM images of PLGA/ascorbic acid - 1232:27:55
SEM images of PLGA/ascorbic acid - 2238:48:22
SEM images of PLGA/ascorbic acid - 3240:32:22
SEM images of PLGA nanospheres242:40:17
SEM images of PLGA /ascorbic acid - 4250:56:04
SEM images of PLGA /ascorbic acid - 5255:43:07
SEM images of PLGA /ascorbic acid - 6257:21:57
In vitro / In vivo258:33:41
In vitro261:58:53
In vivo269:48:26
The radiochemical purity results288:53:56
Organ distribution data in Wistar rats303:22:22
Scheme of the synthesis of the PLGA/folic acid nanoparticles332:19:52
Graph of the linear relationship350:25:49
IR spectra of the PLGA365:29:40
SEM images of particles with different ratio of PLGA and folic acid373:00:45
Comparative results of the stereological study390:37:12
Zeta potential of PLGA dispersion without and with different concentration of folic acid400:30:50
Comparative curves406:44:57
Scheme of obtaining silver nanoparticles412:34:24
UV measurements423:05:24
The temperature effect436:08:49
Time dependant effect441:00:21
The FESEM measurements - 1445:53:12
The FESEM measurements - 2452:47:52
The FESEM measurements - 3461:02:44
The FESEM measurements - 4467:44:01
Induction of intracellular reactive oxygen species480:05:13
FESEM images of PLGA/AgNpPGAs spherical particles488:32:02
Horseradish peroxidase495:38:35
Shematic diagram of manufacturing process for HRP-loaded PLA spheres506:30:09
Graph of the linear relationship514:56:38
FESEM images of HRP-loaded PLA spheres prepared by modified precipitation method523:51:10
Stereological analysis of PLA-HRP spheres based on Dmax.529:54:14
Protein stability536:21:26
Summary540:53:14
References (2007-2011) - 1570:08:38
References (2007-2011) - 2571:07:44
Acknowledgements572:30:58
Thank you!574:12:54