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Remodelling the cellular calcium homeostasis with a synthetic dihydropyrimidone, Nifetepimine: A targeted approach towards immune-rejuvenation and cancer regression
Published on Dec 15, 20141590 Views
In the course of evolution, a number of agents have emerged as carriers of signals that are essential for the correct functioning of cell life. Ca2+ is the most versatile. It nearly triggers all cellu
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Chapter list
Remodelling the cellular calcium homeostasis with a synthetic dihydropyrimidone, Nifetepimine: A targeted approach towards immune-rejuvenation and cancer regression00:00
Calcium: An Ubiquitous Cellular Signal03:01
The SERCA pump04:53
Lymphocyte survival and activation07:07
Cancer acts - 108:01
Cancer acts - 210:37
Tumor-induced CD4+T cell death is associated with SERCA3 over-expression10:59
SERCA pump modulation15:00
A synthetic SERCA pump modulator16:12
SERCA3 over-expression causes ER stress-induced apoptosis17:51
CD4+T cell restoration by nifetepimine involves down regulation of SERCA3 expression - 119:00
CD4+T cell restoration by nifetepimine involves down regulation of SERCA3 expression - 220:42
Tumor shed PGE2 is responsible for CD4+T cell apoptosis - 120:55
Tumor shed PGE2 is responsible for CD4+T cell apoptosis - 223:11
Down-modulation of SERCA by nifetepimine blocks caspase activation and protects T cells from apoptosis23:23
Nifetepimine-induced SERCA3 down modulation causes membrane translocation of PKC isoforms24:34
Genetic manipulation of SERCA3 alters the membrane translocation of the PKC isoforms27:37
Nifetepimine-mediated SERCA3 down modulation promotes NF-κB activation28:46
Nuclear translocation of NF-κB was altered in SERCA3 over expressed and SERCA3 knockdown cells31:33
Validation of the immunoprotective role of Nifetepimine in tumor bearing mice models32:23
Involvement of SERCA in the Nifetepimine-mediated immunorecoveryin tumor-bearing mice models - 134:59
Involvement of SERCA in the Nifetepimine-mediated immunorecoveryin tumor-bearing mice models - 237:02
Nifetepimine - 137:12
Nifetepimine - 237:44
Calcium and Cancer37:50
Nifetepimine induced apoptosis in human mammary carcinoma cells - 138:25
Nifetepimine induced apoptosis in human mammary carcinoma cells - 239:37
Nifetepimine induced breast cancer cell apoptosis involves a rise in the cytosolic calcium level and caspase activation39:58
Nifetepimine regresses cancer in tumor-bearing mice models - 140:50
Nifetepimine regresses cancer in tumor-bearing mice models - 241:52
Nifetepimine - 341:59
Concluding Remarks42:46
Our Hope43:25
Acknowledgements44:57