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Heparin blocks uptake of glioma-derived extracellular vesicles
Published on Mar 14, 20143066 Views
Extracellular vesicles (EVs) have been implicated in tumorigenesis. Biomolecules which can block EV binding and uptake into recipient cells may be of therapeutic value. Here, we show that heparin inte
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Heparin blocks uptake of glioma-derived extracellular vesicles00:00
Glioblastoma multiforme (GBM)01:13
Extracellular vesicles (EVs)01:58
EVs: A New Hallmark of Cancer03:40
Body fluids04:50
Connecting The Dots06:07
Hypothesis08:12
Heparin08:24
EV transfer and block in recipient cells08:53
Heparin blocks transfer of labeled EVs into glioma cells - 110:50
Heparin blocks transfer of labeled EVs into glioma cells - 211:52
Heparin blocks uptake of labeled EVs into primary HUVECs13:06
Heparin causes EV aggregation - 114:36
Heparin causes EV aggregation - 215:47
Heparin binds EVs16:54
Heparin-mediated inhibition of EV-mediated EGFRvIII transfer18:10
Conclusion26:13
Clinical implication29:22
Scientific implication29:43
Is heparin more than a anticoagulant?30:15
Acknowledgments30:24