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Methodology and applications of magnetic resonance imaging (MRI) with hyperpolarized C-13 and He-3 contrast agents
Published on Nov 18, 20114392 Views
Recent innovations in polarization of noble gases and solid state biologically active compounds such as 13C-pyruvate have enable new applications of MRI for the study of functional parameters such as
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Chapter list
Methodology and applications of MRI with hyperpolarized C-13 and He-3 contrast agents00:00
Disclosures00:09
Outline00:33
Severe Gas Trapping in Asthma Subject00:55
Tissue Susceptibility in the Lungs01:52
Collaborations02:30
Spectroscopic Imaging in Brain Glioma Model03:03
NMR Signal03:34
Hyperpolarization vs. Equilibrium Processes03:58
Hyperpolarization Physics05:19
Nuclear Magnetic Dipole Moment06:03
Spin-exchange optical pumping - 106:32
Spin-exchange optical pumping - 208:14
Dynamic Nuclear Polarization (DNP): Solid State Hyperpolarization09:38
Dynamic Nuclear Polarization (DNP)11:23
DNP is versatile11:56
Prototype Commercial SEOP System at UW-Madison13:36
Prototype DNP System14:34
Xenon-129 Polarizer Technology15:32
Outline: Spin relaxation mechanisms16:08
Classical Model of MRI: Magnetic Moments16:36
T1 Decay of Hyperpolarized Agents18:16
T1 Decay for Polarized Agents19:01
T1 and T2 Decay in HP Gases19:54
Longitudinal Signal Decay20:57
T1 and T2 Decay in HP 13C Metabolites21:44
Where to 13C Label?23:14
Outline: Flip angle decay and correction24:14
Signal Decay Due to RF, Flip Angle24:47
Impact on Resolution25:23
k-Space Acquisition25:54
k-Space Signal - 126:52
k-Space Signal - 227:18
Flip angle optimization27:50
Variable Flip Angle28:40
Outline: Oxygen induced decay and map29:17
HP He-3 MRI in Healthy Normal29:24
Longitudinal Signal Decay29:36
Gas Exchange29:52
Example Traces30:43
Multi-Slice Rabbit Data31:48
Outline: Diffusion signal decay32:35
Apparent Diffusion in Emphysema32:41
Lung Microstructure34:28
q-space: Theory35:19
Retrospective Correction37:38
RF and T1 correction39:05
Regional Correction Map39:27
Phantom validation40:12
Comparison of Diffusion Maps40:46
Micro-Structure Dimension41:50
Outline: 13C compounds and metabolic imaging42:05
MR Spectroscopy and Chemical Shift Imaging (CSI)42:22
Chemical Shift Imaging (CSI)43:00
IDEAL Results in Normal Liver (Mouse)43:27
Gyromagnetic Ratio and Consequences44:00
Consideration: Field of View and Gamma44:37
Radial Acquisition45:11
Consideration: Reconstruction45:27
Applications: Motion Correction45:41
Simultaneous 1H/13C Acquisition46:21
Hyperpolarized 13C experiments47:00
Proposed approach: Isolating intracellular signal with gadolinium47:07
Mouse 3: Pre and post Gd spectra47:46
13C MRI Applications48:18
Background on cellular metabolism49:15
UCSF Press Release (RSNA)50:12
Improved approach: spectral spatial excitation50:36
Images zero-filled to 128 x 12850:40
Imaging 7 days after left ureteral obstruction50:45
Summary51:30
Acknowledgements52:16