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Methodology and applications of magnetic resonance imaging (MRI) with hyperpolarized C-13 and He-3 contrast agents
Published on 2011-11-184392 Views
Recent innovations in polarization of noble gases and solid state biologically active compounds such as 13C-pyruvate have enable new applications of MRI for the study of functional parameters such as
Presentation
Methodology and applications of MRI with hyperpolarized C-13 and He-3 contrast agents00:00
Disclosures02:44:53
Severe Gas Trapping in Asthma Subject15:27:16
Tissue Susceptibility in the Lungs31:07:15
Collaborations41:44:20
Spectroscopic Imaging in Brain Glioma Model51:02:14
NMR Signal59:38:09
Hyperpolarization vs. Equilibrium Processes66:22:13
Hyperpolarization Physics88:51:05
Nuclear Magnetic Dipole Moment101:02:22
Spin-exchange optical pumping - 1109:03:07
Spin-exchange optical pumping - 2137:24:53
Dynamic Nuclear Polarization (DNP): Solid State Hyperpolarization160:35:06
Dynamic Nuclear Polarization (DNP)189:49:34
DNP is versatile198:53:48
Prototype Commercial SEOP System at UW-Madison226:47:44
Prototype DNP System242:52:30
Xenon-129 Polarizer Technology258:54:30
Outline: Spin relaxation mechanisms269:07:00
Classical Model of MRI: Magnetic Moments276:40:45
T1 Decay of Hyperpolarized Agents304:32:22
T1 Decay for Polarized Agents317:04:16
T1 and T2 Decay in HP Gases331:54:54
Longitudinal Signal Decay349:20:39
T1 and T2 Decay in HP 13C Metabolites362:22:10
Where to 13C Label?387:25:55
Outline: Flip angle decay and correction404:02:39
Signal Decay Due to RF, Flip Angle413:19:58
Impact on Resolution423:09:15
k-Space Acquisition431:46:55
k-Space Signal - 1447:51:01
k-Space Signal - 2455:09:58
Flip angle optimization464:07:36
Variable Flip Angle477:56:56
Outline: Oxygen induced decay and map488:05:46
HP He-3 MRI in Healthy Normal490:13:59
Longitudinal Signal Decay493:33:28
Gas Exchange497:47:25
Example Traces511:59:35
Multi-Slice Rabbit Data530:06:16
Outline: Diffusion signal decay543:14:01
Apparent Diffusion in Emphysema544:55:32
Lung Microstructure574:34:28
q-space: Theory588:43:11
Retrospective Correction627:14:48
RF and T1 correction651:32:53
Regional Correction Map657:44:39
Phantom validation670:13:15
Comparison of Diffusion Maps679:29:26
Micro-Structure Dimension697:20:03
Outline: 13C compounds and metabolic imaging701:26:10
MR Spectroscopy and Chemical Shift Imaging (CSI)706:13:07
Chemical Shift Imaging (CSI)716:56:29
IDEAL Results in Normal Liver (Mouse)724:14:20
Gyromagnetic Ratio and Consequences733:23:11
Consideration: Field of View and Gamma743:40:06
Radial Acquisition753:04:08
Consideration: Reconstruction757:44:54
Applications: Motion Correction761:38:09
Simultaneous 1H/13C Acquisition772:36:59
Hyperpolarized 13C experiments783:25:42
Proposed approach: Isolating intracellular signal with gadolinium785:25:07
Mouse 3: Pre and post Gd spectra796:22:30
13C MRI Applications805:16:31
Background on cellular metabolism820:57:32
UCSF Press Release (RSNA)836:52:13
Improved approach: spectral spatial excitation843:27:54
Images zero-filled to 128 x 128844:27:06
Imaging 7 days after left ureteral obstruction846:05:30
Summary858:20:59
Acknowledgements871:15:35